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已知锌(Zn)是人体内存在的必须金属离子之一,是金属结合蛋白—金属硫蛋白(MT)的诱导因子。而MT则有使自由基灭活功能。铃木教授等提出自由基与动脉硬化有关,进而研究了Zn对动脉硬化进展的影响。实验选用体重约2kg雄免并分成三组,①是给予1%胆固醇(C)饲料的对照组;②给予1%C饲料加Zn1mg组;③给予1%C加Zn10mg组。经5周饲养后,测定主动脉、动脉病变面积并进行组织学观察。同时测定血清脂质和动脉壁TM。结果:动脉硬化的面积占主动脉总面积的比例是:对照组为9.7%、Zn 1mg组为10.8%、Zn 10mg组为1.2%。可见随Zn的投予量不同而存在差异,但在组
Zinc (Zn) is known to be one of the essential metal ions present in the human body and is an inducer of the metalloprotein-metallothionein (MT). MT has the function of deactivating free radicals. Professor Suzuki proposed free radicals and atherosclerosis related, and then studied the impact of Zn on the progress of atherosclerosis. The experiment selected the body weight of about 2kg male free and divided into three groups, ① is to give 1% cholesterol (C) feed control group; ② give 1% C plus Zn1mg group; ③ give 1% C plus Zn10mg group. After 5 weeks of feeding, the area of the aorta and arterial lesions was determined and the histological observation was performed. Simultaneous determination of serum lipid and arterial wall TM. Results: The area of atherosclerosis in the total area of the aorta was 9.7% in the control group, 10.8% in the Zn 1 mg group and 1.2% in the Zn 10 mg group. It can be seen that there are differences with the amount of Zn administered, but in the group