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近年来,临床应用阿斯匹林(ASA)较为广泛,但其副作用也与日俱增。本文综述有关问题,旨在引起临床重视,以合理应用该药。一、对呼吸系统的影响1.诱发支气管哮喘:早在半个世纪前就发现ASA可诱发支气管哮喘,并称之为“阿斯匹林哮喘”,其发生率为0.2～20%。据Choffee等报告,由ASA类药物引起过哮喘占3.8%,而无哮喘者仅0.9对ASA敏。ASA所致哮喘(即在服用ASA15～30分钟突然发生喘息大发作)的临床表现特点
In recent years, clinical application of aspirin (ASA) is more extensive, but its side effects are also increasing. This article summarizes the relevant issues in order to arouse the clinical attention to rational use of the drug. First, the impact on the respiratory system 1. Induction of bronchial asthma: as early as half a century ago found that ASA can induce bronchial asthma, and called “aspirin asthma,” the incidence was 0.2 to 20%. According to the Choffee et al report, ASA-induced asthma was 3.8%, while those without asthma were only 0.9% ASA-sensitive. ASA-induced asthma (that is, sudden onset of wheezing episodes 15 to 30 minutes after taking ASA)