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长期服用苯妥英钠的癫痫病人可见小脑萎缩,但究竟是苯妥英钠的毒性还是癫痫反复发作所致尚有争论。作者从美国长岛犹太医学中心连续观察119例癫痫病人,其中36例苯妥英钠用药史超过4年,男20例,女16例;年龄21～54岁,平均34.1岁。韦氏成人智力量表测定智商>70。16例为纯复杂性部分发作,另20例在复杂性部分发作后有全身发作。癫痫史3～44年(平均13.7年),最大日剂量300～700mg(平均450mg)。病人均为难治性癫痫,除苯妥英钠外分别合用卡马西平、丙戊酸、鲁米那等抗痫药。酗酒、有围产期疾病、缺氧、癫痫持续状态和神经
Long-term use of sodium phenytoin can be seen in patients with epilepsy cerebellar atrophy, but what is the toxicity of phenytoin or epilepsy caused by repeated episodes is still controversial. The author observed 119 cases of epilepsy patients from the Long Island Jewish Medical Center in the United States. Among them, 36 cases were treated with phenytoin for more than 4 years, including 20 males and 16 females, aged from 21 to 54 years with an average age of 34.1 years. Wechsler Adult Intelligence Scale IQ> 70.16 cases of pure complex partial seizures, and the other 20 cases in the complex part of the seizures have systemic attacks. Epilepsy history of 3 to 44 years (an average of 13.7 years), the maximum daily dose of 300 ~ 700mg (average 450mg). Patients are intractable epilepsy, except for phenytoin combined with carbamazepine, valproic acid, luminal and other anti-epileptic drugs. Alcoholism, perinatal disease, hypoxia, status epilepticus and nerves