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2.南京军区南京总医院解放军临床检分化抑制因子,又称DNA结合抑制因子(Inhibitors of differentiation/DNA binding,Id)属于螺旋-环-螺旋(HLH)转录因子家族成员之一,对碱性HLH(bHLH)转录因子活性起负调节作用。哺乳动物细胞含四种Id分子(Id1-Id4)。Id3,作为血清诱导的立即早期基因1991年第一次在小鼠成纤维细
(2) Inhibitors of differentiation / DNA binding (Id) belong to the member of helix-loop-helix (HLH) transcription factor family, (bHLH) transcription factor activity plays a negative regulatory role. Mammalian cells contain four Id molecules (Id1-Id4). Id3, an immediate early gene induced as a serum-induced fibroblast in mice for the first time in 1991