【摘 要】
：
目的探讨在二乙基己烯雌酚(DES)诱发成年动物生精异常过程中,原癌基因bcl-2、p53及黏附分子cadherin在生精细胞中表达的变化,旨在阐明DES诱发生精异常的作用机理. 方法成年雄
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目的探讨在二乙基己烯雌酚(DES)诱发成年动物生精异常过程中,原癌基因bcl-2、p53及黏附分子cadherin在生精细胞中表达的变化,旨在阐明DES诱发生精异常的作用机理. 方法成年雄性仓鼠皮下注射DES连续7 d后,取其睾丸,进行光镜及电镜的观察和原癌基因bcl-2、p53及黏附分子cadherin的免疫组织化学染色.结果DES处理组的成年仓鼠睾丸生精细胞发育异常,bcl-2和p53表达量均比对照组有显著增加,并以精母细胞和圆形精子细胞较为明显.生精上皮中cadherin的表达比对照组有明显减少.结论DES增加精母细胞和圆形精子细胞表达bcl-2和P53;同时抑制cadherin表达,是诱发成年仓鼠生精异常的原因之一.
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