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目的和方法：本文以131I—BSA和99mTC－DTPA分别作为混合餐固、液体食物的标记物，检测35例慢性胃炎病人和10名健康志愿者的胃排空，其中2例受检者一周内进一步用99mTc－SC复查固体排空，比较两次固体排空过程的相关性。在体外对上述三种放射性标记物在胃液、1mol／LNaCl和0．1mol／LHCl溶液中消化2小时，检测其稳定性。结果：131I—BSA和99mTc－SC标记的固体食物经消化后的脱标率分别＜2．87％和4．63％99mTc－DTPA吸附于固相的吸附率＜8．36％。固／液体排空曲线明显不同，固体排空有明显的延迟期，半排空时间较长，慢性胃炎病人固、液体排空时间均较正常对照组延长，两种固体标记物的排空曲线相似，相关性为γ＝0．989（P＜0．01），前、后两次排空相比，最大差值为9．2％，最小差值仅为0．8％。结论：131I—BSA作为固体标记物有较好的稳定性，可供临床选择用于胃排空的检测。
PURPOSE AND METHODS: Gastric emptying was performed in 35 chronic gastritis patients and 10 healthy volunteers using 131I-BSA and 99mTC-DTPA as a marker for mixed food and solid food, respectively. Two of the subjects underwent gastric emptying within one week The solid was evacuated further with 99mTc-SC, and the correlation between the two solid evacuation processes was compared. The above three radioactive labels were digested in gastric juice, 1 mol / L NaCl and 0.1 mol / LHCl for 2 hours in vitro and the stability was tested. Results: The decolorization rates of 131I-BSA and 99mTc-SC labeled solid foods were <2.87% and 4.63%, respectively. The adsorption rate of 99mTc-DTPA to the solid phase was <8.36%. Solid / liquid evacuation curves were significantly different solid delayed emptying obvious delay, a long half-emptying time, chronic gastritis patients solid and liquid emptying time than the normal control group, the two solid markers of the emptying curve Similarly, the correlation was γ = 0.989 (P <0.01), with a maximum difference of 9.2% and a minimum difference of only 0.8% between the two emptyings before and after emptying. Conclusion: 131I-BSA has good stability as a solid marker for clinical use in the detection of gastric emptying.