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从甲状腺释放到血液循环中的甲状腺素(T_4)和三碘甲状腺原氨酸(T_3),大部分与血浆中的载体蛋白结合。它们是甲状腺素结合球蛋白(TBG)、白蛋白(Alb)和甲状腺素结合前白蛋白(TBPA)。 TBG对T_4、T_3有很高的亲和力,但与T_3的结合不如T_4牢固。Alb结合容量大,亲和力小,结合部分T_4和小部分T_3。TBPA对T_4的亲和力亦比TBG小,不结合T_3。一般认为TBG与T_4的结合,正常人约占其饱和状态的1/3。甲亢患者T_4、T_3增高,结合的多,剩余的TBG结合容量减小;甲减患者相反。血浆中T_4含量、TBG容量一定的情况下
Thyroxine (T_4) and triiodothyronine (T_3) released from the thyroid into the blood circulation, most of which bind to the carrier protein in plasma. They are thyroxine-binding globulin (TBG), albumin (Alb) and thyroxine-binding prealbumin (TBPA). TBG has a high affinity for T_4 and T_3, but not as strong as T_4. Alb binding capacity, affinity, binding part T_4 and a small part of T_3. The affinity of TBPA for T_4 is also smaller than that of TBG, not binding to T_3. It is generally believed that the combination of TBG and T_4, normal population accounts for about one-third of its saturation. Hyperthyroidism patients T_4, T_3 increased, combined with more, the remaining TBG binding capacity decreases; hypothyroidism in patients with the opposite. Plasma T_4 content, TBG capacity under certain circumstances