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布洛芬对有些急性和慢性疼痛有疗效,它的耐受性比其它非甾体抗炎药好,因此被临床广泛使用。它的疗效,特别是镇痛和抗炎作用依赖于剂量、镇痛反应与药物血浆浓度之间直接相关。由于口服含有碱性氨基酸(如赖氨酸、精氨酸等)的溶液出现提前吸收现象,因此本文研究开发了布洛芬的新口服剂型,即含有布洛芬和L-精氨酸的可溶性颗粒小胶囊,并同片剂作比较。用双盲、平衡交叉法对健康志愿者进行药动学和相对生物利用度研究。第一组8名健康男性志愿者(年龄37.2±8.5岁,体重73.5±6.5kg)服用单剂量200mg新口服剂型或相
Ibuprofen is effective in some acute and chronic pain. It is more tolerant than other NSAIDs and is therefore widely used clinically. Its efficacy, especially its analgesic and anti-inflammatory effects, is directly related to the dose, analgesic response and plasma drug concentration. As oral absorption of basic amino acids (such as lysine, arginine, etc.) solution appeared in advance, this paper developed a new oral dosage form of ibuprofen that contains ibuprofen and L-arginine solubility Granules capsules, and compared with the tablet. The pharmacokinetics and relative bioavailability of healthy volunteers were studied by double-blind and balanced crossover. The first group of 8 healthy male volunteers (age 37.2 ± 8.5 years, body weight 73.5 ± 6.5 kg) took a single dose of 200 mg of the new oral dosage form or phase