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用溶媒法制备了利福定固体分散物。经X—射线衍射实验证明,利福定在固体分散物中呈无定形或以分子状态分散于载体中。固体分散物2小时的体外溶出量和人体生物利用度分别较原药提高了88％和21.8％。
Rifidin solid dispersions were prepared by a solvent method. X-ray diffraction experiments show that the rifamycin in the solid dispersion was amorphous or molecularly dispersed in the carrier. Solid dispersion of 2 hours in vitro dissolution and bioavailability were 88% and 21.8% higher than the original drug.