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目的:探讨杭核周因子抗体(APF)对于早期类风湿关节炎(RA)的诊断价值。方法:对70例早期RA患者、90例非RA性自身免疫性疾病患者和50例正常对照者的血清APF和RF进行了测定比较。结果:RA组中APF阳性55例,RF阳性50例;非RA组中无APF阳性,RF阳性25例;正常对照组中无APF阳性,RF阳性1例。APF的特异性为100.0%,RF的特异性为81.4%。经统计学处理,RF的特异性与APF的特异性相比有统计学差异(P<0.01)。结论:APF是RA的特异性血清指标,对早期RA的诊断具有一定价值。
Objective: To investigate the diagnostic value of Hang Zhou factor antibody (APF) for early rheumatoid arthritis (RA). Methods: The serum APF and RF of 70 patients with early RA, 90 patients with non-RA autoimmune disease and 50 normal controls were compared. Results: There were 55 APF positive cases and 50 RF positive cases in RA group. There were no APF positive and RF positive cases in non-RA group. There were no APF positive and RF positive cases in normal control group. The specificity of APF was 100.0% and the specificity of RF was 81.4%. Statistically, RF specificity was significantly different from APF specificity (P <0.01). Conclusion: APF is a specific serum marker of RA, which has some value in the diagnosis of early RA.