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目的:探讨精子形态对体外受精受精率的影响。方法:回顾总结2010年我中心进行常规体外受精(IVF)治疗的561对不育夫妇,按WHO推荐改良巴氏染色方法对精子进行形态学检查,按精子正常形态分为<4%组、4%～9%组、9.5%～14%组和>14%组,分别统计各组精子进行IVF后的受精率。结果:IVF中总受精率为71.00%,精子正常形态<4%组、4%～9%组、9.5%～14%组和>14%组的受精率分别为53.19%、71.33%、71.30%、72.27%。正常形态<4%各组与≥4%各组间的受精率差异有统计学意义(P<0.05)。结论:精子形态对IVF中的受精率有一定影响,精子正常形态低于4%时明显影响IVF的受精率。因此,精子形态分析结果可成为临床上选择IVF还是卵细胞质内单精子注射(ICSI)治疗的参考依据,从而避免一些IVF失败。
Objective: To investigate the effect of sperm morphology on in vitro fertilization rate. Methods: A retrospective review was made on 561 infertile couples who underwent routine IVF treatment in our center in 2010. Morphological examination of the sperm was performed according to the WHO recommendation for improved Pap test. The normal sperm morphology was classified as <4%, 4 % ~ 9% group, 9.5% ~ 14% group and> 14% group. The fertilization rate of sperm in each group after IVF was calculated. Results: The total fertilization rate in IVF was 71.00%. The fertilization rates of normal sperm <4%, 4% ~ 9%, 9.5% ~ 14% and> 14% were 53.19%, 71.33%, 71.30% , 72.27%. The normal fertilization rate of <4% in each group and ≥4% of each group was statistically significant (P <0.05). CONCLUSIONS: Sperm morphology has some influence on fertilization rate in IVF. When sperm normal morphology is less than 4%, fertilization rate of IVF significantly affects. Therefore, the result of sperm morphology analysis can be used as a reference for the clinical selection of IVF or intracytoplasmic sperm injection (ICSI) to avoid some IVF failures.