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目的评价系统性红斑狼疮(SLE)患者左、右心室纵向收缩功能。方法对49例SLE患者(SLE组)与33名健康对照者(对照组)均行超声心动图检查,并应用二维斑点追踪及组织多普勒技术获取三尖瓣瓣环位移(TAPSE)、三尖瓣瓣环等容收缩期速度(IVCv)和三尖瓣瓣环收缩期速度(PSv)。应用QLab 9.0软件分析获得左心室整体纵向应变值(GLS)。结果 SLE组GLS值、TAPSE、IVCv及PSv均低于对照组,差异均有统计学意义(P均<0.01)。SLE组中抗心肌抗体(AMA)阴性者TAPSE和PSv低于对照组(P均<0.05)。GLS与左心室射血分数(LVEF)、TAPSE、IVCv及PSv有一定的相关性(r=-0.57、-0.76、-0.81、-0.78,P均<0.01)。结论 SLE患者左、右心室纵向收缩功能有不同程度的受损。
Objective To evaluate the longitudinal systolic function of left and right ventricles in patients with systemic lupus erythematosus (SLE). Methods Echocardiography was performed on 49 SLE patients and 33 healthy controls (control group). Tricuspid annulus displacement (TAPSE) was obtained by two-dimensional speckle tracking and tissue Doppler imaging. Tricuspid annulus isovolumetric systolic velocity (IVCv) and tricuspid annulus systolic velocity (PSv). Total left ventricular longitudinal strain (GLS) was obtained using QLab 9.0 software. Results The values of GLS, TAPSE, IVCv and PSv in SLE group were significantly lower than those in control group (all P <0.01). The levels of TAPSE and PSv in SLE group were lower than those in control group (all P <0.05). GLS correlated with left ventricular ejection fraction (LVEF), TAPSE, IVCv and PSv (r = -0.57, -0.76, -0.81, -0.78, P <0.01). Conclusion Longitudinal systolic function of left and right ventricle in SLE patients is impaired to some extent.