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目的研究川芎嗪添加治疗帕金森病(PD)的临床疗效。方法将46例PD患者随机分为对照组和观察组;2组均给予美多巴基础治疗,观察组在对照组治疗基础上添加川芎嗪治疗;在治疗前后对2组患者进行统一帕金森病评分量表(UPDRS)各部分评分,并计算2组患者治疗有效率。结果对照组患者治疗后日常生活活动评分和运动检查评分较治疗前显著降低(P<0.05)。观察组患者治疗后精神、行为、情绪评分、日常生活活动评分和运动检查评分较治疗前显著降低(P<0.05)。与对照组治疗后比较,观察组治疗后精神、行为、情绪评分、日常生活活动评分和运动检查评分显著降低(P<0.05)。与对照组比较,观察组治疗有效率显著增高(P<0.05)。结论川芎嗪添加治疗对改善PD患者临床症状效果较好。
Objective To study the clinical efficacy of ligustrazine in the treatment of Parkinson’s disease (PD). Methods Forty-six patients with PD were randomly divided into control group and observation group. Both groups were given basic treatment of metoprolol. The observation group was treated with ligustrazine on the basis of the control group. Before and after treatment, Rating scale (UPDRS) each part score, and calculate the treatment efficiency of two groups of patients. Results After treatment, the scores of daily activities and exercise tests in control group were significantly lower than those before treatment (P <0.05). The mental, behavioral, emotional scores, activities of daily living and motor examination scores in observation group were significantly lower than those before treatment (P <0.05). Compared with the control group after treatment, the observation group’s mental, behavioral, emotional scores, activities of daily living and sports exam scores decreased significantly (P <0.05). Compared with the control group, the observation group, the treatment efficiency was significantly higher (P <0.05). Conclusion Tetramethylpyrazine can improve the clinical symptoms of PD patients better.