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Developing tumor-specific drug delivery systems with minimized off-target cargo leakage re-mains an enduring challenge.In this study,inspired from the natural cryptobiosis explored by certain or-ganisms and stimuli-responsive polyphenol-metal coordination chemistry,doxorubicin(DOX)-conjugated gelatin nanoparticles with protective shells formed by complex of tannic acid and FeⅢ(DG@TA-FeⅢ NPs)were successfully developed as an“AND”logic gate platform for tumor-targeted DOX delivery.Moreover,benefiting from the well-reported photothermal conversion ability of TA-FeⅢcomplex,a synergistic tumor inhibition effect was confirmed by treating 4T1 tumor-bearing mice with DG@TA-FeⅢ NPs and localized near-infrared(NIR)laser irradiation.As a proof of concept study,this work present a simple strategy for developing“AND”logic gate platforms by coating enzyme-degradable drug conjugates with detachable polyphenol-metal shells.