论文部分内容阅读
目的研究多发性骨髓瘤(Multiple myeloma,MM)患者的遗传学特点与临床意义。方法回顾性分析127例MM患者的遗传学结果。结果 127例MM患者中异常染色体检出率为20.3%(35/127),结构畸变多累及1、13、14、17号染色体,复杂畸变的染色体多见,占51.4%(18/35)。核型异常的MM患者对常规化疗疗效差,预后较差,伴有13q14缺失的患者死亡率较不伴有的患者高(P<0.05)。结论 13q14缺失及IgH易位等是MM常见的核型异常,13q14缺失等是预后不良因子。
Objective To study the genetic characteristics and clinical significance of multiple myeloma (MM). Methods Retrospective analysis of 127 patients with MM genetics results. Results The detection rate of abnormal chromosomes in 127 MM patients was 20.3% (35/127). The structural aberrations involved chromosomes 1, 13, 14 and 17, and the chromosomes with complex aberrations were more common, accounting for 51.4% (18/35). MM patients with abnormal karyotype have poor curative effect on conventional chemotherapy and poor prognosis. Patients with 13q14 deletion have higher mortality than those without (P <0.05). Conclusion 13q14 deletion and IgH translocation are the common karyotypic abnormalities in MM. The 13q14 deletion is a poor prognostic factor.