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The aquaporins(AQP)are a family of integral membrane proteins that selectivelytransport water and,in some cases,small neutral solutes such as glycerol andurea.Thirteen mammalian AQP have been molecularly identified and localized tovarious epithelial,endothelial and other tissues.Phenotype studies of transgenicmouse models of AQP knockout,mutation,and in some cases humans with AQPmutations have demonstrated essential roles for AQP in mammalian physiologyand pathophysiology,including urinary concentrating function,exocrine glandu-lar fluid secretion,brain edema formation,regulation of intracranial and intraocu-lar pressure,skin hydration,tat metabolism,tumor angiogenesis and cell migration.These studies suggest that AQP may be potential drug targets for not only newdiuretic reagents for various forms of pathological water retention,but also tar-gets for novel therapy of brain edema,inflammatory disease,glaucoma,obesity,and cancer.However,potent AQP modulators for in vivo application remain to bediscovered.
The aquaporins (AQP) are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol andurea. Tirteen mammalian AQP have been molecularly identified and localized tovarious epithelial, endothelial and other tissues. Phenotype studies of transgenic mice models of AQP knockout, mutation, and in some cases humans with AQP motions have demonstrated essential roles for AQP in mammalian physiology and pathophysiology, including urinary concentrating function, exocrine glandu-lar fluid secretion, brain edema formation, regulation of intracranial and intraocrine pressure, skin hydration, tat metabolism, tumor angiogenesis and cell migration. these studies suggest that AQP may be potential drug targets for not only newdiuretic reagents for various forms of pathological water retention, but also tar-gets for novel therapy of brain edema, inflammatory disease, glaucoma, obesity, and cancer. However, potent AQP modulators for in vivo application rema in to bediscovered