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上皮介质转化(EMT)是指上皮细胞在形态学上发生的向简质细胞或成纤维细胞表型的转变并获得了迁移的能力,它的发生是多基因、多阶段、多步骤的复杂过程.它使在特殊部位产生的上皮细胞从上皮组织分离出来并迁移到其他的位置,是正常发育,伤口愈合以及恶性上皮肿瘤发生的基础.上皮间质转化出现在各种生理和病理的情况下,它在胚胎的发生与器官发育、肿瘤形成、转移以及纤维化过程中均有表达.本文综述了近年来 EMT 与肿瘤的研究进展.“,”The epithelial-mesenchymal transition (EMT) is a complex process with multi-genes, multi-steps and m-ults-stages, where cels undergo a developmental switch from Epithelial phenotype to mesenchymal phenotype and again more Ability of migration. EMT is a fundamental process governing Morphogenes in multcelular organisma. This process is also reactivated in a variety of diseases including fibrosis and carcinoma. This review involves EMT and cancer research progress in recent year.