论文部分内容阅读
目的调查和分析我院抗铜绿假单胞菌感染药物使用情况,提高临床使用抗菌药物的合理性。方法回顾性调查铜绿假单胞菌感染病人107例(188株铜绿假单胞菌),分析抗菌药物使用情况。采用药物利用评价的方法计算用药频度(DDDs)。主要依据《抗菌药物临床应用指导原则》判断用药合理性。结果研究发现易感人群以老年、伴发多种基础疾病、住院时间长的病人居多,临床感染类型主要以肺部感染和尿路感染为主。DDDs排列前6位的分别是哌拉西林-三唑巴坦,头孢哌酮-舒巴坦,头孢米诺,美罗培南,左氧氟沙星和环丙沙星。结论我院治疗铜绿假单胞菌感染以选择β-内酰胺酶抑制剂复合制剂为主,临床工作中应重视易感人群的病原学监测以指导用药、控制感染,并加强抗菌药物合理使用的管理。
Objective To investigate and analyze the use of anti-Pseudomonas aeruginosa in our hospital to improve the rationality of clinical use of antimicrobial agents. Methods A total of 107 patients with Pseudomonas aeruginosa infection (188 strains of Pseudomonas aeruginosa) were retrospectively analyzed for the use of antibacterials. Medication use frequency (DDDs) was calculated using drug utilization evaluation. Mainly based on “clinical guidelines for antimicrobial agents” to determine the rationality of medication. Results The study found that most of the susceptible population were elderly, patients with multiple underlying diseases and long hospital stay. The main types of clinical infection were pulmonary infection and urinary tract infection. The top 6 DDDs were piperacillin-tazobactam, cefoperazone-sulbactam, cefminox, meropenem, levofloxacin, and ciprofloxacin. Conclusions In our hospital, the treatment of Pseudomonas aeruginosa infection is based on the selection of β-lactamase inhibitors. In clinical work, we should pay attention to the etiological monitoring of susceptible people to guide the medication, control the infection and enhance the rational use of antibiotics management.