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目的 :探讨食管鳞状细胞癌组织中细胞胀亡与凋亡的存在及 2者间的关系。方法 :收集 30例食管鳞状细胞癌标本 ,利用透射电镜、TUNEL及免疫组织化学技术检测其中的胀亡、凋亡细胞及微血管密度 (MVD)。结果 :食管鳞状细胞癌组织中存在胀亡及凋亡细胞 ,凋亡指数 (AI)和胀亡指数 (OI)分别为 (1 .7± 1 .2 )和 (3.2± 1 .9)。与MVD低表达组比较 ,高表达组OI较低 ,而AI较高 ,差异有统计学意义 (P <0 .0 0 1或P <0 .0 0 5 )。结论 :食管鳞状细胞癌存在凋亡和胀亡两种细胞死亡方式 ,2者的存在及分布与MVD有关。
Objective: To investigate the existence of cell apoptosis and apoptosis in esophageal squamous cell carcinoma and the relationship between them. Methods: Thirty esophageal squamous cell carcinoma specimens were collected and their oncotic cells, apoptotic cells and microvessel density (MVD) were detected by transmission electron microscopy, TUNEL and immunohistochemistry. Results: There were swollen and apoptotic cells in esophageal squamous cell carcinoma, and the apoptotic index (AI) and inflation index (OI) were (1.7 ± 1.2) and (3.2 ± 1.9). Compared with MVD low expression group, OI in high expression group was lower and AI was higher, the difference was statistically significant (P <0.01 or P <0.05). Conclusion: The esophageal squamous cell carcinoma has two kinds of cell death modes of apoptosis and expansion, the existence and distribution of the two are related to MVD.