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24小时尿雌三醇值是了解胎儿胎盘功能单位的较好指标之一。但收集24小时尿不完整率高达50％,可导致雌三醇值偏低,干扰临床诊断。为此,我们测定72例正常孕妇20～42周各孕周24小时尿标本498份的雌三醇(E_3)及肌酐(C)值,以了解两者的关系。结果表明:1.各孕周尿肌酐均值相对稳定,其正常范围为0.60～1.40g/24h。凡是尿量收集完整的标本肌酐值都大于0.60g/24h。2.经测定肌酐值校对的尿标本基础上,建立了本院实验室正常妊娠20～42周各孕周E_3值及E_3/C比值的均数曲线。两者呈高度相关(r=0.994);对尿肌酐值偏离1愈多者,应用E_3/C比值后其变异度较E_3者可减少一半以上。可以认为E_3/C比值更能合理反映胎儿胎盘功能。
24-hour urinary estriol value is to understand one of the better indicators of fetal placental function units. However, collecting 24-hour urinary impermeability rates as high as 50% can lead to low estriol values that interfere with clinical diagnosis. For this purpose, we measured the values of E_3 and creatinine (C) in 498 urine samples of 24 normal pregnant women from 24 weeks of gestational weeks in 72 normal pregnant women to understand their relationship. The results showed that: (1) The mean urinary creatinine was stable in each gestational week with the normal range of 0.60 ~ 1.40g / 24h. All urine samples collected creatinine values are greater than 0.60g / 24h. On the basis of urine samples calibrated by creatinine, mean curves of E_3 and E_3 / C ratios of each gestational week in normal pregnancy from 20 to 42 weeks in our hospital were established. (R = 0.994). When the deviation of urinary creatinine was more than 1, the variation of E_3 / C ratio could be reduced by more than half as compared with E_3. E_3 / C ratio can be more reasonable to reflect fetal placental function.