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目的 按不同病理类型分类探讨特殊型乳腺癌发病的危险因素,为乳腺癌的预防提供依据。方法 对诊断为特殊型乳腺癌的患者进行1:2配比的病例对照研究,各因素的比值比和95％可信限的计算采用条件Logistic回归方法,连续变量的趋势检验采用X~2检验法。结果 单因素分析表明:乳腺炎病史、初产年龄(≥27岁)、初潮初产间隔(≥10年)、性格内向、生活事件总分、遇事忍受、乳腺癌家族史,Quet指数(≥37)、哺乳期奶量不足等因素可增加患特殊型乳腺癌的危险性;母乳喂养及初潮年龄(≥14岁)是保护因素。多因素分析结果表明:初产年龄大于等于27岁、初潮初产间隔大于等于10年、性格内向、生活事件总分及乳腺癌家族史是特殊型乳腺癌发生的危险因素,初潮年龄大于等于14岁是保护因素。结论 初潮年龄、初产年龄、初潮初产间隔、精神心理因素、遗传因素等与特殊型乳腺癌的发生有明显的关系。
Objective To explore the risk factors for the pathogenesis of breast cancer according to different pathological types, so as to provide evidence for the prevention of breast cancer. Methods A 1:2 matching case-control study was performed on patients diagnosed with specific breast cancer. The odds ratios and 95% confidence limits for each factor were calculated using Conditional Logistic Regression, and the continuous variable trend test was X~2 test. law. Results Univariate analysis showed that the history of mastitis, the age of first birth (≥27 years old), the interval between menarche (≥10 years), introverted personality, total score of life events, tolerance for failure, family history of breast cancer, Quet index (≥ 37) Lack of lactating milk can increase the risk of breast cancer; breastfeeding and menarche age (≥14 years) are protective factors. The results of multivariate analysis showed that the age of first birth is greater than or equal to 27 years, the interval between the first birth of menarche is greater than or equal to 10 years, the introversion, the total number of life events, and the family history of breast cancer are risk factors for the occurrence of special breast cancer. The menarche age is greater than or equal to 14 Age is a protective factor. Conclusion The age of menarche, the age of first birth, the interval of menarche, the psycho-psychological factors, and genetic factors have a significant relationship with the occurrence of special breast cancer.