论文部分内容阅读
目的探讨奈达铂联合多西他治疗食管癌术后患者的临床效果。方法选取2012年10月—2014年10月于山西省肿瘤医院接受手术治疗的食管癌患者92例,随机分为对照组与治疗组,各46例。对照组患者术后予以多西他赛联合顺铂治疗,治疗组患者术后予以多西他赛联合奈达铂治疗。两组患者临床效果、并发症(粒细胞减少、口腔黏膜炎、放射食管炎、胃肠道反应)发生情况、症状控制时间、化疗时间、复发情况及病灶转移情况。结果治疗组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患者粒细胞减少、口腔黏膜炎、放射食管炎、胃肠道反应发生率低于对照组,差异有统计学意义(P<0.05);治疗组患者症状控制时间和化疗时间短于对照组,差异有统计学意义(P<0.05);治疗组患者复发和病灶转移率低于对照组,差异有统计学意义(P<0.05)。结论奈达铂联合多西他赛治疗食管癌术后患者的临床效果显著,可缩短症状控制时间和化疗时间,且并发症少,患者复发和病灶转移率低。
Objective To investigate the clinical effect of nedaplatin plus docetaxel in the treatment of postoperative esophageal cancer patients. Methods 92 patients with esophageal cancer undergoing surgery in Shanxi Cancer Hospital from October 2012 to October 2014 were randomly divided into control group and treatment group, with 46 cases in each group. Patients in the control group were treated with docetaxel and cisplatin after operation, and patients in the treatment group were treated with docetaxel combined with nedaplatin after operation. Two groups of patients clinical effects, complications (neutropenia, oral mucositis, esophageal radiation, gastrointestinal reactions) the occurrence of symptom control time, chemotherapy, recurrence and lesion metastasis. Results The total effective rate of treatment group was higher than that of control group, the difference was statistically significant (P <0.05); the incidence of neutropenia, oral mucositis, radiation esophagitis and gastrointestinal reaction in treatment group was lower than that in control group (P <0.05). The symptom control time and chemotherapy time in the treatment group were shorter than those in the control group (P <0.05). The recurrence and the metastasis rate in the treatment group were lower than those in the control group Statistical significance (P <0.05). Conclusion Nedaplatin combined with docetaxel in the treatment of postoperative esophageal cancer patients with significant clinical results, can reduce the symptom control time and chemotherapy time, and fewer complications, patients with recurrence and lesion metastasis rate is low.