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本文采用随机单盲拉丁方设计,使8名健康志愿者分别按不同顺序口服安慰剂和40,80,120mg/d普萘洛尔各两天,测定其心脏收缩时间间期(STI),静息和极量运动心率、血压和稳态血药浓度。实验观察到:口服普萘洛尔后,在STI指标中:LVETI缩短PEP(PEPI)和ICT延长,PEP/LVET增大。但只有对照组与大剂量普萘洛尔组的差别有显著性。而QA_2和IRP无显著性改变。实验还可观察到:口服普萘洛尔后静息和极量运动心率明显减慢。普萘洛尔血浆浓度与静息心率抑制率相关性差,而与极量运动心率抑制率相关性较好。静息和运动收缩压也降低,而舒张压则无明显改变。因而我们认为STI指标和极量运动心率的抑制可用来反映普萘洛尔β-阻滞作用中的负性肌力和负性频率作用。但STI指标不够敏感,而极量运动试验在临床上受病情的限制为其缺点。
In this paper, a randomized single blind Latin square design, so that eight healthy volunteers, respectively, in different order of oral placebo and 40,80,120mg / d propranolol two days, measured systolic time (STI), resting And extreme exercise heart rate, blood pressure and steady-state plasma concentration. It was observed experimentally that after oral administration of propranolol, in STI indicators: LVETI shortened PEP (PEPI) and ICT prolongation, and PEP / LVET increased. However, only the difference between the control group and the high-dose propranolol group was significant. However, QA 2 and IRP had no significant changes. Experiments can also be observed: oral propranolol after rest and extreme exercise significantly slowed heart rate. Propranolol plasma concentration and resting heart rate inhibition rate of poor correlation, but with extreme exercise heart rate inhibition rate is good. Resting and exercise systolic blood pressure also decreased, while diastolic blood pressure did not change significantly. Thus, we believe that the inhibition of STI and maximal exercise heart rate may be used to reflect the negative inotropic and negative effects of propranolol β-blockade. However, STI index is not sensitive enough, and extreme exercise test in the clinical limitations of the disease as its drawbacks.