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胃复安又名灭吐灵(Metoclopramide),是目前治疗消化性溃疡的新药之一。它于1961年合成,1964年报道了有关此药的最早药理研究。十余年来,对此药的研究陆续有报道。现将该药的临床应用及副作用简要介绍如下。治疗消化系统疾病该药目前在临床上主要用来治疗溃疡病、胃炎及幽门梗阻等。其药理作用是增强胃窦部收缩,调节胃窦和十二指肠球部的动力,从而加速胃的排空,这样胃内容物与胃粘膜接触的时间缩短,胃窦释放胃泌素减少。此药还能防止十二指肠液反流入胃,因而本药适用于治疗胃溃疡和胃炎。此外,它也能增加食管下端括约肌的张力,防止胃液反
Metoclopramide, also known as Metoclopramide, is currently one of the new drugs for the treatment of peptic ulcer. It was synthesized in 1961, and the earliest pharmacological studies on this drug were reported in 1964. More than ten years, the study of this drug one after another have been reported. Now the clinical application of the drug and side effects briefly described below. Treatment of digestive diseases The drug is currently mainly used in the clinical treatment of ulcer disease, gastritis and pyloric obstruction. Its pharmacological effect is to enhance the contractions of gastric antrum, regulate the motility of the antrum and the duodenal bulb, thus accelerating the emptying of the stomach, thus shortening the contact time of the gastric contents with the gastric mucosa and reducing the release of gastrin in the gastric antrum. This drug can also prevent duodenal fluid reflux into the stomach, so the drug is suitable for the treatment of gastric ulcer and gastritis. In addition, it can also increase the tension of the lower esophageal sphincter to prevent gastric fluid