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作者报告日本Kole大学医院及Kole儿童医院1981～1987年间经活检诊断为IgA肾病儿童患者共154例。随机选择1984年以前的70例患者重复活检,并对其中61例患者进行了临床——病理对照研究。所有154例患者在初次活检时均符合原发性IgA肾病。第二次活检的61例按临床表现分为两组即无蛋白尿,无血尿(尿常规检查正常),血压正常,肾功能正常者(Ⅰ组)23例;有血尿和/或蛋白尿者(Ⅱ组)38例。病理切片由一位医师在完全不了解临床资料的情况下进行观察。每一切片中至少有5个肾小球。系膜增殖程度分如下3级即1)微小病变:大部分肾小球正常,少数有轻度系膜基质增多;2)局灶性系膜增殖,80%以下的肾小球显示出中至重度系膜基质增多和/或中至重度系膜
The authors report a total of 154 children diagnosed with IgA nephropathy by biopsy in Japan’s Kole University Hospital and Kole Children’s Hospital from 1981 to 1987. Seventy patients were randomized to repeat biopsies prior to 1984 and 61 of them were studied clinically-pathologically. All 154 patients met primary IgA nephropathy at initial biopsy. The second biopsy according to the clinical manifestations of 61 cases were divided into two groups of proteinuria, no hematuria (normal urine test), normal blood pressure, normal renal function (group Ⅰ) 23 cases; with hematuria and / or proteinuria (Group Ⅱ) 38 cases. The pathology was observed by a physician without any knowledge of the clinical data. There are at least 5 glomeruli in each section. Mesangial proliferation in the following three grades that 1) minimal change: most of the glomerular normal, a few mild mesangial matrix increased; 2) focal mesangial proliferation, below 80% of the glomeruli showed moderate to Severe mesangial matrix increased and / or moderate to severe mesangial