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硫唑嘌呤是肾脏移植中广泛使用的一种免疫抑制剂,长期应用可以发生白细胞减少和骨髓轻度巨幼红细胞改变。作者报道2例应用硫唑嘌呤诱发的单纯红细胞性再障(以下称纯红再障)。此2例,1例为18岁女性,1例为33岁男性,均于肾移植后发生了贫血。前者于肾移植后曾使用硫唑嘌呤150mg/天及强的松历6年,后者于肾移植前曾间断使用约2年而于肾移植后持续使用硫唑嘌呤200mg/天及强的松历1年。因贫血入院时,前者血
Azathioprine is a widely used immunosuppressive agent in kidney transplantation. Long-term use can lead to leukopenia and changes in bone marrow microcytic mesenchymal cells. The authors reported two cases of azathioprine induced erythrocytic aplastic anemia (hereinafter referred to as pure red aplastic anemia). The two patients, one 18-year-old female and one 33-year-old male, developed anemia after renal transplantation. The former used azathioprine 150mg / day and prednisone for 6 years after kidney transplantation. The latter was used intermittently for about 2 years before kidney transplantation and continued with azathioprine 200mg / day and prednisone after kidney transplantation Calendar for 1 year. Because of anemia admission, the former blood