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目的探讨血液中某些微量元素水平与出生缺陷的关系。方法用原子吸收光谱法对48例有出生缺陷的新生儿和产妇血液进行Cu、Zn、Fe、Pb、Cd 5种元素测定,随机选取30例健康正常产妇及新生儿做对照比较。结果出生缺陷儿与健康正常儿血中Cu、Zn、Fe含量差异有统计学意义(P<0.01);Pb、Cd为有害元素,含量也差异有统计学意义(P<0.05)。健康母、脐血中Cu、Zn、Fe含量差异有统计学意义(P<0.01),而有出生缺陷的母、脐血Cu、Zu、Fe和Pb、Cd含量差异无统计学意义(P>0.05)。结论微量元素对胚胎的发育有重要影响,缺乏或过多均会导致出生缺陷;正常母-胎间有元素屏障功能,功能异常可致出生缺陷,有害元素可致出生缺陷。
Objective To explore the relationship between blood levels of certain trace elements and birth defects. Methods The concentrations of Cu, Zn, Fe, Pb and Cd in 48 cases of neonates with maternal birth defects and maternal blood were measured by atomic absorption spectrometry. 30 healthy normal maternal and newborns were randomly selected for comparison. Results The contents of Cu, Zn and Fe in children with normal birth defects and normal children were statistically significant (P <0.01). The contents of Pb and Cd in the children with healthy children were also significantly different (P <0.05). The contents of Cu, Zn and Fe in healthy mother and umbilical blood were significantly different (P <0.01), but there was no significant difference in the content of Cu, Zu, Fe, Pb and Cd between the mother and umbilical cord blood (P> 0.05). Conclusion Microelement has an important influence on the development of embryos. The lack of or excess can lead to birth defects. The normal mother-fetus has elemental barrier function. Abnormal function can cause birth defects, and harmful elements can cause birth defects.