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侵袭转移是恶性肿瘤的主要症状和致死原因,而细胞形状的改变是肿瘤早期浸润转移的重要原因之一,这些改变与细胞骨架的重排和肌动蛋白结合蛋白的聚集形成伪足密切相关。Fascin是一种能与F-actin结合的细胞骨架蛋白,其在肿瘤的发生、浸润、转移中具有重要作用。目前,令人关注的是Fascin作用的调节受多种信号传导通路的调控,但
Invasion and metastasis are the main symptoms and cause of death of malignant tumors. The change of cell shape is one of the important reasons of tumor invasion and metastasis. These changes are closely related to the rearrangement of cytoskeleton and the aggregation of actin-binding protein. Fascin is a cytoskeletal protein that binds to F-actin, which plays an important role in tumorigenesis, invasion and metastasis. Currently, it is of concern that the regulation of Fascin’s action is regulated by a variety of signaling pathways, but