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目的:探讨米非司酮和米索前列醇联合依沙吖啶终止中期妊娠的临床效果。方法:选择笔者所在医院近年来收治的终止中期妊娠患者162例,根据终止妊娠方法不同分为治疗组和对照组,对照组采用依沙吖啶终止妊娠,治疗组在对照组治疗基础上加用米非司酮联合米索前列醇终止妊娠,比较两组的引产效果、软产道损伤及不良反应情况。结果:治疗组孕妇均引产成功,成功率为100%;对照组有64例引产成功,成功率为84.2%,治疗组引产成功率明显高于对照组,差异有统计学意义(P<0.05)。治疗组15例(17.4%)有胎膜残留,对照组有44例(57.9%)胎盘胎膜残留,均给予常规清宫,治疗组清宫率明显低于对照组,差异有统计学意义(P<0.05)。治疗组出现规律宫缩平均时间、平均引产时间均明显短于对照组,差异有统计学意义(P<0.01);治疗组胎儿娩出后2h内平均出血量明显少于对照组,差异有统计学意义(P<0.01)。结论:米非司酮和米索前列醇联合依沙吖啶终止中期妊娠,安全、可靠、成功率高,是中期妊娠引产较为理想的治疗方法,值得临床推广应用。
Objective: To investigate the clinical efficacy of mifepristone and misoprostol in combination with ethacridine to terminate the second trimester pregnancy. Methods: Select the author’s hospital in recent years admitted to terminate the 162 cases of midterm pregnancy, according to the method of termination of pregnancy is divided into treatment group and control group, the control group with ethacridine termination of pregnancy, the treatment group in the control group based on the treatment Mifepristone combined with misoprostol termination of pregnancy, induction of labor effects in both groups, soft birth canal injury and adverse reactions. Results: The successful rate of induction of labor in the treatment group was 100%. In the control group, 64 cases were successful induction of labor, the success rate was 84.2%. The successful rate of induction of labor in the treatment group was significantly higher than that in the control group (P <0.05) . In the treatment group, 15 cases (17.4%) had residual fetal membranes. In the control group, 44 cases (57.9%) had residual membranes of the placenta. All patients were given routine nocturnal clearance. The clearance rate in the treatment group was significantly lower than that in the control group (P < 0.05). The treatment group had regular contractions of the average contractions time, the average induction of labor time were significantly shorter than the control group, the difference was statistically significant (P <0.01); 2h after treatment, the average amount of bleeding was significantly less than the control group, the difference was statistically Significance (P <0.01). Conclusion: Mifepristone and misoprostol combined with ethacridine termination of mid-term pregnancy, safe, reliable, high success rate is the mid-term pregnancy induction of labor is an ideal treatment, it is worthy of clinical application.