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屡有报道,认为脱氧胆酸(DCA)在胆固醇结石形成中可能起有作用。但关于胆结石发病机制的权威性评论并未提到这种可能性。每天到达结肠的循环胆盐不超过10%,未被末端回肠吸收的任何一种胆酸到结肠时,经过厌氧菌的7α-脱羟基作用后,很快转变为DCA,新形成的DCA1/3～1/2通过被动扩散被吸收,并进行再循环,DCA循环池约500mg。老年人、女性、高甘油三脂血症及食肉类者常伴有胆汁内DCA浓度增高,美国一项胆结石协作对包括280例男子在内的几个人群组的研究表明,十二指肠胆酸中的DCA比例与胆囊中胆汁(或肝内胆汁)的胆固醇克分子量%或胆固醇饱和指数(CSI)之间有
It has been reported repeatedly that DCA may play a role in the formation of cholesterol calculus. But the authoritative commentary on the pathogenesis of gallstones does not mention this possibility. Every day to reach the colon circulation bile salt not more than 10%, not by the terminal ileum absorption of any bile acids to the colon, after anaerobic bacteria 7α-dehydroxylation, quickly converted to DCA, the newly formed DCA1 / 3 to 1/2 are absorbed by passive diffusion and recycled, about 500 mg for the DCA circulation. Elderly, women, hypertriglyceridemia and carnivores are often associated with elevated concentrations of DCA in the bile. A cohort study of 280 gallbladders in the United States showed that duodenal There is a relationship between the DCA ratio in bile acid and the% cholesterol or cholesterol saturation index (CSI) in bile (or intrahepatic bile) in the gallbladder