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目的:探讨凝血异常对慢性阻塞性肺疾病急性加重(AECOPD)合并呼吸衰竭患者预后的影响。方法:AE-COPD合并呼衰患者80例,检测动脉血气(PO2)、计算氧和指数(PaO2/FiO2)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、抗凝血酶Ⅲ(AT-Ⅲ)、D-二聚体(D-Dimer)水平。结果:死亡组患者PT、APTT延长,AT-Ⅲ减低,FIB、D-Dimer增加,与生存组比较差异有统计学意义(P<0.01)。结论:AECOPD合并呼衰患者凝血功能异常程度与预后有关。
Objective: To investigate the effect of coagulation abnormalities on the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and respiratory failure. Methods: Eighty patients with AE-COPD were enrolled in this study. Arterial blood gas (PO2), oxygenation index (PaO2 / FiO2), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), antithrombin Ⅲ (AT-Ⅲ) and D-Dimer. Results: The death of patients with PT, APTT prolonged, AT-Ⅲ decreased, FIB, D-Dimer increased, compared with the survival group was statistically significant (P <0.01). Conclusion: The degree of coagulation dysfunction in AECOPD patients with respiratory failure is related to the prognosis.