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采用０ 、１ 、２ 月免疫程序，对４８０ 名 Ｈ Ｂｓ Ａｇ 、抗 Ｈ Ｂｓ 、抗 Ｈ Ｂｃ 均阴性的６ ～１２ 岁小学生进行为期３ 年的３ 批国产重组酵母乙肝疫苗和１ 批美国同类疫苗免疫效果观察。首剂疫苗免疫后３ 个月时，两种疫苗的抗体阳转率达９２ ％ ；６ 个月时，阳转率均在９８ ％ 以上；３ 年时，仍维持在９０ ％ 以上；３ 个月、６ 个月及３６ 个月４ 批疫苗的抗体滴度（ Ｇ Ｍ Ｔ） 分别在８２５７ ｍ Ｉ Ｕ／ｍｌ 、９２６１ ｍ Ｉ Ｕ／ ｍｌ 和１１９７２ ｍ Ｉ Ｕ／ ｍｌ 以上。但６ 个月及３ 年时，两种疫苗的抗体滴度有显著性差异。结果显示：国产重组酵母乙肝疫苗具有较好的免疫效果和安全性；采用０ 、１ 、２ 月免疫程序，可较早地诱导机体产生较高水平的抗体，但其免疫效果稍逊于美国疫苗。
Three batches of three-year domestic recombinant yeast Hepatitis B vaccine and one batch of American Hp vaccine were administered to 480 primary school students aged 6-12 years with negative HbsAg, anti-Hbs and anti- Hbc using 0, 1, and 2 immunization programs. Immunization effect of similar vaccine. At 3 months after the first dose of vaccine, the positive rate of antibody positive rate of the two vaccines reached 92%. At 6 months, the positive rate of positive rate was over 98%; at 3 years, the rate of antibody positive rate remained above 90% The antibody titer (G M T) of the four batches of vaccine at 6 and 36 months were 8257 m I U / ml, 9261 m I U / ml and 11972 m I U / ml, respectively. However, there was a significant difference in antibody titers between the two vaccines at 6 and 3 years. The results showed that the domestic recombinant yeast Hepatitis B vaccine had good immunogenicity and safety. The immunization program of 0, 1, and 2 months could induce the body to produce higher levels of antibody earlier, but its immunogenicity was lower than that of the U.S. vaccine .