Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

• 作 者: Zhi-Kun Qiu Dong Shen Yin-Shen
• 机 构: StateKeyLaboratoryofOncologyinSouthChina,DepartmentofNeurosurgery/Neuro-oncology,DepartmentofPharmac
• 出 处: 癌症：英文版
• 发表日期: 2014年2期
• 关键词: 神经胶质瘤 MGMT 替莫唑胺 干细胞 耐药性 DNA甲基转移酶 NF-κB 核因子-κB Glioma stem cell MGMT temozolomi
• 基金项目: supported by the National Natural Science Foundation of China(No.30772551),the Science &Technology Program of Guangdong Province(No.2011B031800178),National High-technology Research and Developmen

O6-methylguanine DNA methyltransferase(MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contributing to the drug resistance of gliomas to alkylating agents. In addition, glioma stem-like cells(GSCs) have been demonstrated to be i