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作者测定了4周～8月龄婴儿初次接种DTP后的百日咳凝集素滴度,重点观察初次接种年龄和时间间隔对凝集素形成的影响。婴儿初免DTP的年龄为4周～8月龄,大腿前部肌肉注射,注射剂量为0.5ml。每次接种前后采集静脉血。完成2针或3针基础免疫后1、3、6、9和12个月,以及加强免疫后1、3和6个月分别采血。用微量法测定凝集素滴度,≥1∶80为高应答,1∶10～1∶40为低应答,而<1∶10为阴性。用参考血清作对照,滴度波动在+/-1个倍比稀释度。
The authors measured pertussis lectin titer after initial DTP in infants aged 4 weeks to 8 months and focused on the effects of initial vaccination age and time interval on lectin formation. Initial DTP for infants The age of 4 weeks to 8 months old, anterior thigh muscle injection, the injection dose of 0.5ml. Venous blood was collected before and after each inoculation. Blood samples were taken at 1, 3, 6, 9 and 12 months after completion of 2 or 3 doses of primary immunization and at 1, 3 and 6 months after booster immunization. Lectin titers were determined by the microtiter method with> 1: 80 high response, 1:10 - 1:40 low response and <1:10 negative. Reference serum was used as a control and the titre was varied at +/- 1 fold dilution.