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正常大白鼠腹腔注射胍乙啶每周3次,每次15—30毫克/公斤,共3周后,血压无明显变化。DOCA型高血压大白鼠给同剂量的胍乙啶组与对照组,在继续给DOCA的情况下,“浄升、降压面积百分比”分别为-1％和9％。两者相差10％,说明对DOCA型高血压大白鼠血压的继续上升,胍乙啶趋于抑制,腹腔注射20毫克/公斤的胍乙啶可使大白鼠的嗜酸性白血球和肾上腺中的抗环血酸含量在0.5—6小时内降低,但肾上腺内胆固酵含量的减低尚不明显。以上结果说明胍乙啶稍能影响腎上腺皮质的活动。
Normal mice intraperitoneal injection of guanethidine three times a week, each 15-30 mg / kg, a total of 3 weeks after no significant change in blood pressure. DOCA-type hypertensive rats given the same dose of guanethidine group and control group, continue to DOCA cases, the “net rise, the percentage of areas under the pressure” were -1% and 9%. Difference between the two 10%, indicating that DOCA-type hypertension in rats continued to rise in blood pressure, guanethidine tended to inhibit the intraperitoneal injection of 20 mg / kg of guanethidine can rat eosinophilic white blood cells and adrenal anti-ring Acid content decreased within 0.5-6 hours, but the reduction of adrenal solid fermentation was not significantly reduced. The above results indicate that guanethidine slightly affects adrenal cortical activity.