论文部分内容阅读
肿瘤细胞是由于正常细胞丧失了生长调控而表现出无限制生长等一系列的恶性行为,且这一行为能稳定地传递给子代细胞。这一事实表明,在肿瘤发生过程中经历了遗传物质的改变,而这些改变必然会反映在作为遗传物质载体的染色体上。多年来,许多细胞遗传学家和肿瘤遗传学家一直致力于寻找恶性肿瘤的特异性染色体改变,试图由此探索肿瘤发生的机理。但由于方法学上的限制,进展缓慢。Nowell
Tumor cells are a series of malignant behaviors such as unlimited growth due to loss of growth regulation of normal cells, and this behavior can be stably transmitted to progeny cells. This fact indicates that genetic changes have taken place during tumorigenesis and these changes are bound to be reflected in the chromosomes that serve as genetic vectors. Over the years, many cytogenetics and tumor genetics have been dedicated to finding specific chromosomal alterations in malignancies in an attempt to explore the mechanisms of tumorigenesis. However, progress has been slow due to methodological limitations. Nowell