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目的从个体和群体角度研究ＨＣＶ和ＨＢＶ在ＨＣＣ高危人群中的病因学意义及病因协同作用．方法将１９８９－１９９３年期间在江苏省启东、泰兴两地ＨＣＣ高危人群中获得的１４０例ＨＣＣ患者和２４７例对照血清，进行ＨＢＶ、ＨＣＶ血清学指标检测和非条件Ｌｏｇｉｓｔｉｃ回归分析，比较各指标的危险度（ＯＲ）值和ＰＡＲ（％），并进行统计学显著性检验．结果在抗ＨＣＶ分别阳性和阴性的ＨＣＣ病例中，其ＨＢＶ各指标间的阳性率均无显著差异；ＨＢＶ各指标和抗ＨＣＶ的阳性率均以病例组显著高于对照组，Ｐ值均小于００１，单因素非条件Ｌｏｇｓｔｉｃ回归分析可见，感染不同ＨＢＶ指标者患ＨＣＣ的ＯＲ值和ＰＡＲ值可相差数倍，以ＨＢｓＡｇ阳性的危险性最大，ＯＲ和ＰＡＲ值分别为９４９和５８７９％，抗ＨＣＶ的ＯＲ值也较高，在４１３～４８５之间，由于人群感染抗ＨＣＶ阳性率较低（３６４％），其ＰＡＲ仅为１１３７％～１１９１％，ＨＢｓＡｇ和抗ＨＣＶ重叠感染的ＯＲ值为７０７１，远高于两者单独感染的ＯＲ值之积．结论ＨＣＶ与ＨＢＶ对高危人群中ＨＣＣ的发生有病因协同作用，对个体发生ＨＣＣ的估计相对ＯＲ两者相差不大，而对群体发生的ＨＣＣ的人群归因危?
Objective To study the etiology and etiological synergy of HCV and HBV in high-risk groups of HCC from the perspective of individuals and groups. Methods 140 serum HCC patients and 247 control sera obtained from HCC at high risk in Qidong and Taixing in Jiangsu Province during 1989-1993 were tested for serological markers of HBV and HCV and unconditional logistic regression analysis. The risk (OR) value and PAR (%) were tested statistically. Results There was no significant difference in the positive rates of HBV among the HCC cases with positive and negative anti-HCV respectively. The positive rates of HBV and anti-HCV were significantly higher in the case group than in the control group. Less than 001, univariate unconditional Logstic regression analysis showed that the OR and PAR values of HCC infected with different HBV markers may differ by several times. The risk of HBsAg positive is the highest, the OR and PAR values are 949 and 58 79%, the anti-HCV OR value is also high, between 4 13 ～ 4 85, because the population infected with anti-HCV positive rate is relatively low (3 64%), its PAR is only 11 37 From 91% to 11%, the OR value of HBsAg and anti-HCV overlap infection was 7071, which was much higher than the OR of the two infections alone. Conclusions HCV and HBV have etiological synergistic effects on the occurrence of HCC in high-risk populations. There is no significant difference in the relative OR of individual HCC estimates, and the risk of population-based HCC is attributable to the population.