【摘 要】
：
Precisely analyzing the target materials in living cells can reveal the essence and mystery of life at a deeper level,which will provide reliable theoretical basis for the occurrence,development,treatment and prognosis of major diseases.However,because li
【机 构】
：
State Key Laboratory of Biogeology and Environmental Geology,Faculty of Materials Science and Chemis
论文部分内容阅读
Precisely analyzing the target materials in living cells can reveal the essence and mystery of life at a deeper level,which will provide reliable theoretical basis for the occurrence,development,treatment and prognosis of major diseases.However,because living cells are in the dynamic process of metabolism,there are several challenges existed in accurate analysis,including subcellular compartment heterogeneity,plasma membrane interface barrier,and cell cycle regulation.In this regard,our group has designed and synthesized a series of multifunctional aggregates by mainly integrating the peptide elements,nucleic acid elements and aggregation elements to overcome the barriers.This article summarizes the latest developments of multifunctional aggregates for precise cell analysis by our group,and systematically introduces them according to different design concepts and targeting dimensions,such as space,efficiency as well as time.We hope this work could contribute to analyzing the biomarkers in cells through constructing the multifunctional aggregates,understanding the operation mechanism of cells,finally inspiring technology breakthroughs in biomedical fields.
其他文献
We conducted a three-month field experiment focusing on the physical and chemical characteristics of fog in a tropical rainforest in Xishuangbanna,Southwest China,in the winter of 2019.In general,the fog would form at midnight and persist because of the i
Polymer solar cells (PSCs) featuring nonfullerene acceptors have attracted a great deal of attention in the research community.Exposure of these active layers to sunlight during operation demands excellent thermal stability.Optimizing PSCs often requires
Based on a 16-warm-season statistical study on the mesoscale convective systems (MCSs) that were generated over the Tibetan Plateau (TP),11 long-lived eastward propagating MCSs of the same type were selected for a composite semi-idealized simulation and a
Sclerophyllous evergreen broad-leaved forests,mainly made up of sclerophyllous oak,Quercus section Hetero-balanus (Φerst.) Menitsky,Fagaceae,represent the most typical forest type in the Hengduan Mountains.Their distribution pattern is closely related to
Atmospheric refractivity fields are more strongly affected by more water vapor in the tropical lower troposphere than elsewhere.In this study,based on model simulations,we first collocated the radio occultation (RO) data in 2009 from the Constellation Obs
Hollow metal-organic frameworks (HoMOFs) as emerging materials have been arousing great interest in heterogeneous catalysis with respect to the solid counterparts,mainly because of their unique and intriguing features such as high surface to volume ratio,
Rechargeable ion batteries are one of the most reliable energy storage technologies for the applications ranging from small portable devices and electric vehicles to renewable energy integration and large-scale stationary energy storage.In the roadmap of
Rechargeable aluminum batteries (RABs) have attracted great interest as one of the most promising candidates for large-scale energy storage because of their high volumetric capacity,low cost,high safety and the abundance of aluminum.However,compared with
Following the age of directing group,anchoring catalysis starts coming to the center of the stage.Different from the directing-group strategy that needs a preinstalled directing group in substrates,anchoring catalysis relies on a reversible interaction be
China\'s Mars exploration mission has stimulated tremendous interest in planetary science exploration recently.To propose potential scientific research projects,this study presents a concept simulation for the measurement of Martian atmo-spheric winds u