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正常肺泡上皮细胞的表面覆盖着一层很薄的由血浆超滤及局部分泌而成的物质,它能维持上皮细胞的构型以利于气体交换。其中含有多种物质,包括血浆蛋白中的转铁蛋白、铜蓝蛋白及维生素E、维生素C和还原型谷胱甘肽。成人呼吸窘迫综合征(ARDS)是一种非心源性肺水肿,特点是肺血管通透性增强导致蛋白和体液进入肺间质和肺泡腔并伴有急性炎症反应,故此时肺泡内表面的液体成份会有很大变化。最近已有报道ARDS时肺部清除水肿的能力,但对肺泡内液体的抗氧化能力却少有报道。肺淋巴瘘动物模型有利于同时研究与肺有关的三个腔隙:血清可反映血管内的变化,淋巴液反映间质,支气管肺泡灌洗液反映肺内气体空间的炎症和免疫反应。本实验旨在研究羊
The surface of normal alveolar epithelial cells is covered with a thin layer of material that is ultrafiltered and locally secreted by plasma and maintains epithelial cell configuration to facilitate gas exchange. It contains a variety of substances, including plasma proteins transferrin, ceruloplasmin and vitamin E, vitamin C and reduced glutathione. Adult respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema characterized by increased pulmonary vascular permeability resulting in the entry of proteins and body fluids into the pulmonary interstitium and alveolar space with an acute inflammatory response, Liquid ingredients can vary greatly. The ability of the lungs to clear edema has been recently reported in ARDS, but the antioxidant capacity of the alveolar fluid is seldom reported. Pulmonary lymphatic fistula animal model is conducive to the simultaneous study of lung-related three lacunae: serum can reflect changes in the blood vessels, lymph, interstitial, bronchoalveolar lavage fluid reflects the gas space in the lung inflammation and immune response. This experiment aims to study sheep