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目的:探讨尼尔雌醇联合米索前列醇用于绝经后妇女取IUD的临床疗效。方法:选择2008年6月~2009年6月长兴县人民医院收治的96例绝经后取器妇女为研究对象,随机分为观察组和对照组各48例。对照组给予尼尔雌醇,观察组在此基础上服用米索前列醇。比较两组宫颈软化、术前不良反应、取器效果及手术情况。结果:观察组宫颈完全软化率、软化率分别为89.6%、100.0%,均明显高于对照组的72.9%、85.4%,两组差异有统计学意义(P<0.05);观察组不良反应发生率为20.8%,明显低于对照组的41.7%,两组差异有统计学意义(P<0.05);观察组取器顺利率和成功率分别为83.3%、97.9%,均明显高于对照组的50.0%、83.3%,两组差异有统计学意义(P<0.05);观察组手术时间、出血量和宫颈损伤均明显优于对照组,两组差异有统计学意义(P<0.05)。结论:尼尔雌醇联合米索前列醇能够发挥协同作用,大大提高宫颈软化率和取器成功率,减少不良反应,是绝经后妇女取IUD的简单、安全、有效方法,值得临床进一步推广应用。
Objective: To investigate the clinical efficacy of nylestriol combined with misoprostol in the treatment of IUD in postmenopausal women. Methods: 96 cases of postmenopausal women who were taken from Changxing County People’s Hospital from June 2008 to June 2009 were selected as research object and randomly divided into observation group and control group, 48 cases each. The control group was given nilestriol, and the observation group took misoprostol on the basis of this. Compare the two groups of cervical softening, preoperative adverse reactions, the effects of the device and surgical conditions. Results: The complete softening rate and softening rate of the cervix in the observation group were 89.6% and 100.0%, respectively, which were significantly higher than those in the control group (72.9% and 85.4%, respectively) (P <0.05). Adverse reactions occurred in the observation group The rate was 20.8%, significantly lower than 41.7% of the control group, the difference between the two groups was statistically significant (P <0.05); the successful rate of the device was 83.3% and the success rate of 97.9% in the observation group were significantly higher than the control group (P <0.05). The operation time, blood loss and cervical injury in the observation group were significantly better than those in the control group, with significant difference between the two groups (P <0.05). Conclusion: Nilestriol combined with misoprostol can play a synergistic effect, greatly improve the rate of cervical softening and success rate of removal, reduce adverse reactions, is a simple, safe and effective method for IUD in postmenopausal women, it is worth further clinical application .