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目的控讨凋亡抑制蛋白Survivin在膀胱移行细胞癌(BTCC)和正常膀胱移行上皮细胞中的表达与意义。方法采用免疫组织化学技术(S-P法)检测56例膀胱移行细胞癌,16例正常膀胱组织凋亡抑制蛋白Survivin的表达,分析其表达情况与肿瘤病理分级、临床分期的关系。结果Survivin在正常膀胱移行上皮细胞中不表达,膀胱移行细胞癌组织中Survivin的阳性表达百分率为70%,Survivin在正常膀胱移行上皮细胞和BTCC中的表达之间有显著性差异(P<0.01)。结论Survivin是膀胱癌的分子标志物之一,可望用于膀胱癌的辅助诊断和预后判断。
Objective To investigate the expression and significance of Survivin in bladder transitional cell carcinoma (BTCC) and normal bladder transitional epithelial cells. Methods The expression of Survivin in 56 cases of bladder transitional cell carcinoma and 16 cases of normal bladder tissue was detected by immunohistochemical technique (S-P method). The relationship between the expression of Survivin and the tumor grade and clinical stage was analyzed. Results Survivin was not expressed in normal bladder transitional epithelial cells. The positive expression rate of Survivin in bladder transitional cell carcinoma was 70%, and the expression of Survivin was significantly different between normal bladder transitional epithelial cells and BTCC (P <0.01) . Conclusion Survivin is one of the molecular markers of bladder cancer and is expected to be used in the diagnosis and prognosis of bladder cancer.