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目的 探讨P5 3、CerbB 2基因蛋白在膀胱癌中的分布及意义。方法 应用ABC免疫组织化学法 ,对 66例人体膀胱癌进行研究。结果 P5 3、CerbB 2蛋白在正常膀胱粘膜中表达均阴性 ,P5 3蛋白在膀胱癌中的阳性率为 5 3 % ;CerbB 2蛋白在膀胱癌中的阳性率为 4 5 %。P5 3蛋白在 2a内复发肿瘤的阳性率高于 2a后复发肿瘤 ,相互间差异具有统计学意义 (P <0 .0 5 ) ,CerbB 2蛋白在 2a内复发肿瘤的阳性率低于 2a后复发肿瘤 ,相互间差异不具有统计学意义 (P >0 .0 5 )。结论 P5 3和CerbB 2基因蛋白表达均与膀胱癌的恶性程度有关 ,且P5 3蛋白对预后估计有一定的参考价值
Objective To investigate the distribution and significance of P5 3 and CerbB 2 gene proteins in bladder cancer. Methods ABC immunohistochemical method was used to study 66 cases of human bladder cancer. Results The expression of P5 3 and CerbB 2 protein was negative in normal bladder mucosa. The positive rate of P53 protein in bladder cancer was 53%. The positive rate of CerbB 2 protein in bladder cancer was 45%. The positive rate of P53 protein recurrence in 2 years was higher than that of recurrence after 2 years (P < 0.05). The recurrence rate of CerbB 2 protein in 2 years was less than 2 years after recurrence. Tumors were not statistically different from each other (P > 0.05). Conclusion The expression of P5 3 and CerbB 2 gene proteins are related to the degree of malignancy of bladder cancer, and P5 3 protein has a certain reference value for the estimation of prognosis.