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目的探讨血清降钙素原(procaleitonin,PCT)对新生儿细菌感染性疾病早期诊断的意义。方法回顾性分析新生儿科收治的61例患儿,按出院诊断分成感染组和非感染组,其中感染组有35例,非感染组有26例,人院当天应用抗生素治疗前采3 ml静脉血作PCT检测,用酶联荧光免疫技术测定其PCT值,以PCT≥0.5 ng/ml为阳性,对两组患儿降钙素原检测结果进行对比,用统计软件SPSS 19.0进行数据分析。结果 61例新生儿中,感染组的PCT阳性率为94.29%,非感染组的PCT阳性率为11.54%,差异有统计学意义(P<0.05)。结论 PCT对新生儿细菌感染性疾病诊断具有较高的敏感度,对新生儿细菌感染引起全身性感染性疾病早期诊断优势明显。
Objective To investigate the significance of serum procalitonin (PCT) in the early diagnosis of neonatal bacterial infectious diseases. Methods Retrospective analysis of 61 cases of neonates admitted to the hospital, divided into infectious and non-infected group according to the diagnosis of discharge, of which 35 cases of infection group, non-infected group of 26 cases, the day of hospital antibiotics treatment with 3 ml of venous blood before treatment The PCT values were determined by enzyme-linked immunosorbent assay (ELISA) and PCT (0.5 ng / ml) were positive. The results of procalcitonin were compared between the two groups. The data were analyzed by statistical software SPSS 19.0. Results Among the 61 newborns, the positive rate of PCT was 94.29% in the infected group and 11.54% in the non-infected group, the difference was statistically significant (P <0.05). Conclusions PCT is sensitive to the diagnosis of bacterial infectious diseases in neonates and has obvious advantages in the early diagnosis of systemic infectious diseases caused by bacterial infections in newborns.