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目的:观察早期乳腺癌患者行吡柔比星联合卡培他滨(AX)辅助化疗方案的不良反应及生活质量。方法:对60例实施AX方案和60例实施吡柔比星联合环磷酰胺(AC)方案的乳腺癌患者进行不良反应登记,并通过乳腺癌生活质量量表进行生活质量调查,比较两者的反应情况。结果:AX方案呕吐、严重呕吐(III/IV级)发生率明显低于AC方案(53.3%vs.75.0%,P=0.013;10.0%vs.25.0%,P=0.031);AX方案手足综合征发生率明显高于AC方案(45.0%vs.11.7%,P=0.001),但严重手足综合征发生率两者差异无统计学意义(3.3%vs.0,P=0.154);骨髓抑制、恶心、腹泻、脱发以及心脏不适及严重不良反应(III/IV级)发生率两组差异无统计学意义。生活质量功能领域调查显示,AX方案在个人角色、社会功能领域得分明显高于AC方案(78.40 vs.70.92,P=0.042;81.00 vs.75.33,P=0.035),躯体、情绪、认知功能得分两组无统计学差异(均P>0.05)。结论:AX方案与传统AC方案比较,前者给药简便,呕吐及严重呕吐发生率低,患者整体生活质量更高。
Objective: To observe the adverse reactions and quality of life of patients with early breast cancer undergoing adjuvant chemotherapy with pirarubicin combined with capecitabine (AX). Methods: Sixty patients with breast cancer who underwent AX regimen and 60 patients who received pirarubicin combined with cyclophosphamide (AC) regimen were enrolled in the Adverse Drug Reactions Inventory and quality of life survey was conducted using the Quality of Life Scale for Breast Cancer Reaction situation. Results: The incidence of vomiting and severe vomiting (III / IV) in the AX regimen was significantly lower than that in the AC regimen (53.3% vs. 75.0%, P = 0.013; 10.0% vs.25.0%, P = 0.031) (45.0% vs.11.7%, P = 0.001). However, the incidence of severe hand-foot syndrome was not significantly different between the two groups (3.3% vs.0, P = 0.154); myelosuppression, nausea , Diarrhea, hair loss and the incidence of cardiac discomfort and serious adverse reactions (III / IV) were not statistically different between the two groups. A survey of quality of life functional areas showed that the AX program scores were significantly higher in the individual role and social function areas than in the AC program (78.40 vs. 70.92, P = 0.042; 81.00 vs. 75.33, P = 0.035), and physical, emotional and cognitive function scores There was no significant difference between the two groups (all P> 0.05). Conclusion: Compared with the traditional AC regimen, AX regimen has the advantages of simple administration, low incidence of vomiting and severe vomiting, and higher overall quality of life in patients.