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嗜中性细胞在机体防御中起着极为重要的作用,包括杀灭细菌和杀伤肿瘤细胞等等。其通过趋化、摄入,细胞内杀灭、消化和释放溶酶体复合物而对入侵的微生物起反应。产生活性氧(超氧化阴离子(superoxide anions. O_2~-)、过氧化氢(H_2O_2)和羟基(.OH)等)是杀菌机制中的一个基本因素。在静息细胞中主要由超氧化形成NADPH氧化酶(superoxide-forming NADPH oxidase)催化产生过氧化产物。在此酶的激活过程中钙起第二信使作用。而钙通过胞浆膜和从细胞内钙贮存部位进入胞浆。有许多实验表明:挥发性麻醉药如氟烷、安氟醚、异氟醚在一定程度上抑制活性氧的产生,
Neutrophils play an extremely important role in body defense, including killing bacteria and killing tumor cells and so on. It reacts to invading microorganisms by chemotaxis, ingestion, intracellular killing, digestion and release of lysosomal complexes. Production of reactive oxygen species (superoxide anions, O 2 -, H 2 O 2 and hydroxyl groups (OH)) is a basic factor in the bactericidal mechanism. In resting cells, superoxide is catalyzed by superoxide-forming NADPH oxidase. Calcium plays a second messenger role in the activation of this enzyme. While calcium enters the cytoplasm through the cytoplasmic membrane and from the intracellular calcium stores. There are many experiments show that: volatile anesthetics such as halothane, enflurane, isoflurane to some extent inhibit the production of reactive oxygen species,