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目的探讨外周血抗内皮细胞抗体(antiendothelial cell antibodies,AECA)与瘦素的相关性及其在子痫前期(preeclampsia,PE)发病中的作用。方法 20例子痫前期孕妇为观察组,20例正常晚期孕妇为对照组,采用ELISA法检测2组外周血AECA及瘦素水平,ROC曲线分析其诊断子痫前期的价值。结果对照组血清AECE和瘦素水平((49.92±13.09)pmol/L和(23.65±5.24)μg/L)高于观察组((26.38±17.83)pmol/L和(14.33±5.35)μg/L),差异均有统计学意义(P<0.05);观察组血清AECA水平与瘦素水平呈正相关(r=0.463,P=0.010);AECA>57.7pmol/L时诊断子痫前期的灵敏度为90%,特异度为90%;瘦素>17.05μg/L时诊断子痫前期的灵敏度为80%,特异度为80%。结论血清AECA、瘦素水平升高可能通过血管内皮损伤与炎症反应参与子痫前期的发病。
Objective To investigate the correlation between peripheral blood anti-endothelial cell antibodies (AECA) and leptin and its role in the pathogenesis of preeclampsia (PE). Methods Twenty pregnant women with preeclampsia were selected as the observation group and 20 normal pregnant women as the control group. The levels of AECA and leptin in peripheral blood were detected by ELISA. The diagnostic value of ROC curve in preeclampsia was analyzed. Results The levels of serum AECE and leptin in the control group (49.92 ± 13.09 pmol / L and 23.65 ± 5.24 μg / L) were significantly higher than those in the observation group (26.38 ± 17.83 pmol / L and 14.33 ± 5.35 μg / L ), The differences were statistically significant (P <0.05). The serum AECA level in the observation group was positively correlated with leptin level (r = 0.463, P = 0.010). The sensitivity of the diagnosis of preeclampsia was 90% when AECA> 57.7pmol / L %, Specificity of 90%; leptin> 17.05μg / L when the diagnosis of preeclampsia sensitivity was 80%, specificity was 80%. Conclusion Serum AECA and leptin levels may be involved in the pathogenesis of preeclampsia through vascular endothelial injury and inflammation.