维吾尔族2型糖尿病患者Calpain10基因分型及其环境影响因素

• 作 者: 李琳琳 张月明 杜景玉 毛新民 冉新建 王长辉 李念东 孙晓风 林仁勇 杨永新
• 机 构: 新疆医科大学药学院药理教研室,新疆医科大学公卫学院营养教研室,新疆医科大学药学院药理教研室,新疆医科大学药学院药理教研室,新疆医科大学基础医学院机能中心,新疆乌鲁木齐市军区总医院口腔科,新疆医科大学药
• 出 处: 疾病控制杂志
• 发表日期: 2006年03期
• 关键词: 环境 维吾尔族 糖尿病 非胰岛素依赖型

目的探索Calpain10基因SNP43及部分环境因素对新疆地区维吾尔族T2DM易感性的影响。方法采用ARMS-PCR对54例T2DM患者和107例NGT人群Calpain10基因SNP43进行基因分型,并对部分环境因素进行logistic逐步回归分析。结果①与NGT组相比,SNP43的A等位基因频率升高。②文化程度高、动物内脏摄入量大、血胆固醇高与T2DM的发生呈正相关,而饮茶、水果摄入适中与其呈负相关。结论Calpain-10 SNP43 A等位基因可能与维吾尔族T2DM相关。文化程度高、动物内脏摄入量大、血胆固醇高等因素是维吾尔族T2DM发生的危险因素,饮茶、适量水果摄入是其发生的保护因素。

Objective To explore the effect of SNP43 of Calpain10 gene and some environmental factors on the susceptibility of T2DM in Uygur nationality in Xinjiang. Methods The genotypes of Calpain10 gene SNP43 in 54 patients with T2DM and 107 patients with NGT were genotyped by ARMS-PCR, and some environmental factors were analyzed by logistic stepwise regression. Results ① Compared with NGT group, SNP43 A allele frequency increased. ② higher education level, higher visceral intake, high blood cholesterol level and the occurrence of T2DM were positively correlated, while tea, fruit intake was moderately negative correlation. Conclusion The allele of Calpain-10 SNP43 A may be related to Uygur T2DM. High level of education, animal offal intake, high blood cholesterol and other factors is Uygur T2DM risk factors, drinking tea, the amount of fruit intake is its protective factors.