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为进一步探讨抗核心糖脂域单克隆抗体（ＭＡｂ）的免疫保护效果及其可能的作用机制，以小鼠脓毒症为模型，用产色鲎试验法和细胞因子活性检测等方法，研究了抗核心糖脂域ＭＡｂ（ＥＬ１、ＥＬ３和３Ｈ４）对实验性脓毒症小鼠的存活及其血中ＬＰＳ、ＴＮＦ－ａ和ＩＬ－６水平的影响。结果表明，这三株ＭＡｂ均能显著提高受ＬＰＳ及Ｅ．ｃｏｌｉ攻击小鼠的存活率（Ｐ＜０．０５）；且有明显降低小鼠血中ＬＰＳ、ＴＮＦ－ａ和ＩＬ－６水平的作用，提示抗核心糖脂域ＭＡｂ的保护作用与其中和ＬＰＳ的活性，从而达到降低ＬＰＳ诱导小鼠效应细胞释放炎性细胞因子的作用有关。
In order to further explore the immunoprotective effect of anti-core glycolipid domain monoclonal antibody (MAb) and its possible mechanism, using mouse sepsis as a model, using the method of chromogenic assay and cytokine activity assay, Effects of anti-core glycolipid domain MAb (EL1, EL3 and 3H4) on the survival of experimental septic mice and the level of LPS, TNF-a and IL-6 in blood. The results showed that all three MAb can significantly improve by LPS and E. (P <0.05), and significantly decreased the levels of LPS, TNF-a and IL-6 in the blood of mice, suggesting that the protective effect of MAb against central glycolipid and the neutralization of LPS Activity, so as to reduce the LPS-induced release of inflammatory cytokines in effector cells.