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目的 :测定幽门螺杆菌 (HP)感染的慢性胃炎患儿血清中白介素 6 (IL - 6 )、白介素 8(IL - 8)、肿瘤坏死因子α(TNF -α)水平变化的意义 ,了解其发病机制。方法 :采用美国DPC公司的IMMULITE全自动化学发光分析仪检测慢性胃炎患儿和正常对照组血清中的IL - 6 ,IL - 8和TNF -α含量。结果 :慢性胃炎患儿血清中IL - 6浓度为 5 .4 8± 0 .79pg/ml,IL - 8浓度为 14 .34± 8.2 9pg/ml,TNF -α浓度为 13.4 5± 5 .80 pg/ml;对照组血清IL - 6 ,IL - 8和TNF -α分别为 5 .10± 1.10 pg/ml,6 .70± 2 .10 pg/ml和 8.0 0± 2 .10pg/ml,两组IL - 8,TNF -α含量经t检验 ,t值分别为 4 .4 9和 4 .4 6 ,P <0 .0 1差异有显著性 ,且慢性胃炎患儿血清中IL - 8与TNF -α含量呈正相关。结论 :IL - 6 ,IL - 8和TNF -α参与HP感染的慢性胃炎的发病。
Objective: To determine the significance of serum levels of IL - 6, IL - 8 and TNF - α in children with chronic gastritis infected with Helicobacter pylori (HP) mechanism. Methods: The levels of IL - 6, IL - 8 and TNF - α in sera of children with chronic gastritis and normal controls were detected by IMMULITE automatic chemiluminescence analyzer from American DPC Company. Results: The levels of IL - 6 in serum of children with chronic gastritis were 5.58 ± 0.79pg / ml, IL - 8 was 14.34 ± 8.29pg / ml and the concentration of TNF - α was 13.4 5 ± 5.80 pg / ml; the serum IL - 6, IL - 8 and TNF - α in the control group were respectively 5.10 ± 1.10 pg / ml, 6.70 ± 2.10 pg / ml and 8.0 ± 2 .10 pg / ml, The levels of IL - 8 and TNF - α in serum of children with chronic gastritis were significantly lower than those of patients with chronic gastritis (t = 4.49 and 4.46, respectively) α content was positively correlated. Conclusion: IL - 6, IL - 8 and TNF - α are involved in the pathogenesis of HP infection in chronic gastritis.