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钙拮抗剂除对心绞痛、心律失常、高血压及高血压危象、雷诺氏病、心功能不全等已有较好疗效以外,近年也试用于心肌病、支气管哮喘、食管贲门失驰缓症、迟发性倾倒综合征(反应性低血糖)以及用于心肌保护和与抗癌药物并用等方面。1.试用于心肌病:岸本等对梗阻型者6例,给以静注硫氮(艹卓)酮(diltiazem),一次10mg,5分钟后,其左室—主动脉间压力差从对照值(平均)33mmHg上升到47mmHg,15分钟后降至39mmHg。用药5分钟时末梢血管阻力最小,15分钟恢复到原水平。同时可见病人在安静时右室等容舒张时间减少,舒张障碍改善,左室输出时间系数在运动时增加。因而左室内压力差减少,改善了本病的舒张功能障碍。作者是在住院时静脉给药,确有疗效后改为门诊口服(90～180mg/日)治疗。但要小心钙拮抗剂有扩张末梢血管作用,有增加左室流出经路梗阻的危险。
In addition to angina pectoris, arrhythmia, hypertension and hypertensive crisis, Raynaud’s disease, heart failure and other effects have been better, in recent years also tested for cardiomyopathy, bronchial asthma, esophageal cardia deacetylate, Delayed dumping syndrome (reactive hypoglycemia) and for myocardial protection and anti-cancer drugs and so on. 1. Trying for cardiomyopathy: Kishimoto on obstruction in 6 cases, given intravenous diltiazem (diltiazem) (diltiazem) (diltiazem), a 10mg, 5 minutes after the left ventricular pressure difference between the control value (Average) 33 mmHg to 47 mmHg, dropping to 39 mmHg after 15 minutes. 5 min drug peripheral vascular resistance minimum, 15 minutes to restore the original level. At the same time shows that patients in the quiet right ventricular relaxation time decreased diastolic dysfunction, left ventricular output time coefficient increased during exercise. Thus reducing the pressure difference between the left ventricle to improve the diastolic dysfunction of the disease. The author is in the hospital intravenous administration, indeed after the change to the clinic oral (90 ~ 180mg / day) treatment. But be careful calcium antagonists have the role of dilation of peripheral blood vessels, increased risk of left ventricular outflow obstruction.